Experts at Oxford are active in genome engineering research to better understand, study and treat human disease.
Various research programmes across the Medical Sciences Division at Oxford are exploring a range of different approaches to genome engineering for treating human disease and to develop research tools with broad application. Current research projects include:
- Gene therapy for cystic fibrosis and choroideremia (a type of blindness)
- Viral immunotherapy for colorectal cancer
- Detection and analysis of mutagenesis in drosophila
With recent advances around the use of transcription activator-like effector nucleases (TALENs) and programmable RNA-guided endonucleases (CRISPR/Cas9) being hailed as major breakthroughs, there is much interest in this field and its potential across biomedical research.
Areas of Genome engineering expertise at Oxford include:
- Designing and producing attenuated viruses for cancer immunotherapy
- Designing and assessing viral and non-viral vectors for human gene therapy
- Generation of transgenic animal models
- Designing and testing sgRNA molecules for use in the CRISPR/Cas9 system
Companies interested in consultancy in this area should contact the Consulting Services team.