Genome engineering

Experts at Oxford are active in genome engineering research to better understand, study and treat human disease.

Various research programmes across the Medical Sciences Division at Oxford are exploring a range of different approaches to genome engineering for treating human disease and to develop research tools with broad application. Current research projects include:

  • Gene therapy for cystic fibrosis and choroideremia (a type of blindness)
  • Viral immunotherapy for colorectal cancer
  • Detection and analysis of mutagenesis in drosophila

With recent advances around the use of transcription activator-like effector nucleases (TALENs) and programmable RNA-guided endonucleases (CRISPR/Cas9) being hailed as major breakthroughs, there is much interest in this field and its potential across biomedical research.

Areas of Genome engineering expertise at Oxford include:

  • Designing and producing attenuated viruses for cancer immunotherapy
  • Designing and assessing viral and non-viral vectors for human gene therapy
  • Generation of transgenic animal models
  • Designing and testing sgRNA molecules for use in the CRISPR/Cas9 system

Companies interested in consultancy in this area should contact the Consulting Services team.

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