Humanized PD-1 Knock-In Mouse Model

Strain: hPD-1KI, Gene: PDCD1, Background: C57BL/6

The Programmed Cell Death 1 receptor (PD1) is expressed on various immune cells, including T-cells, NKT-cells and B-cells. The level of PD-1 expression and the extent to which it is engaged by its two natural ligands is thought to regulate T-cell activation, providing a basis for therapeutic intervention via agents either stimulating or blocking the receptor. However, to date, there has been a lack of tools to enable in vivo validation of such therapies.

Homozygous transgenic “knock-in” mice expressing human/mouse chimeric PD-1 on a C57BL/6 background. The exon encoding the ligand binding V-set IgSF domain of the endogenous murine pdcd1 gene has been swapped for the equivalent exon from the human PDCD1 gene. Expression has been confirmed.

PD1 monoclonal antibody reagent also available from Oxford University Innovation (Product Code: 7696)


The University’s policy is to minimise the use of animals in research, consistent with the need to make significant advances on important problems of human health. Where animal research is necessary, the University will provide housing and care that exceeds, wherever possible, legal requirements. The University will also continually pursue techniques that reduce the number of animals involved in research. For further information about animal research at Oxford, click here.


The information presented here on these pages has been provided by the scientists and academics who have created the reagents. As far as Oxford University Innovation is able to establish this information is accurate but no representation is given as to its accuracy or completeness. It is the responsibility of the customer to determine the suitability for any purpose of the reagents and Oxford University Innovation shall not be liable for any claims, losses, liabilities, expenses or damages arising from any use of the materials. Nothing on these pages will form part of any contract or licence nor be regarded as a warranty or representation in relation to the products. Any supply would be subject to the terms and conditions of a separate agreement. Oxford University Innovation makes no representation that any item in this catalogue is not subject to third party intellectual property rights.

Request more

Ready to get in touch?

Contact Us
© Oxford University Innovation