Humanized PD-1 Knock-In Mouse Model

Strain: hPD-1KI, Gene: PDCD1, Background: C57BL/6

The Programmed Cell Death 1 receptor (PD1) is expressed on various immune cells, including T-cells, NKT-cells and B-cells. The level of PD-1 expression and the extent to which it is engaged by its two natural ligands is thought to regulate T-cell activation, providing a basis for therapeutic intervention via agents either stimulating or blocking the receptor. However, to date, there has been a lack of tools to enable in vivo validation of such therapies.

Homozygous transgenic “knock-in” mice expressing human/mouse chimeric PD-1 on a C57BL/6 background. The exon encoding the ligand binding V-set IgSF domain of the endogenous murine pdcd1 gene has been swapped for the equivalent exon from the human PDCD1 gene. Expression has been confirmed.

PD1 monoclonal antibody reagent also available from Oxford University Innovation (Product Code: 7696)

 

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