Optimising exosome loading and targeting ability using transmembrane protein

Applications: Targeted drug delivery

A single-pass EV transmembrane protein used to improve extracellular vesicle/exosome loading and cell targeting. The membrane topology enables simultaneous loading of protein cargos in the exosome lumen, and attachment of a targeting moiety on the exosome surface. It exhibits intrinsic cleavage potential, enabling the release of the cargo protein into recipient cells.

Features	Benefits
Single spanning transmembrane protein	Guarantee cargo protein and target moiety are in same vesicle No additional protein scaffold required Ensures accuracy when targeting
Small transmembrane protein, only 180 amino acids	Similar or improved loading capacity than CD63 and PTGFRN Higher delivery efficiency than CD63
Protein is of human origin	Prevents immune responses to the technology
Cells naturally take up exosomes from their surroundings	Potential for use in loading exosomes with protein cargos, ribonucleoprotein complexes (e.g.AGO2/siRNA, Cas9/sgRNA)
Efficient and simple method	Reduces time and labour costs

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Optimising exosome loading and targeting ability using transmembrane protein

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