2,5 dibromohexane diamide/2,3diiodo hexanediamide hybridoma

Reagents for the mild conversion of cysteine to dehydroalanine.

Using these reagents the conversion of cysteine to dehydroalanine proceeds at near neutral pH (8.0) and at 37°C with short reaction times (2-3 hours), this can be advantageous for fragile protein substrates such as antibodies and histones. The reagents can be used for site specific synthesis of S-linked glycoproteins, to incorporate mimics of posttranslational modifications and to generate amino acids with unnatural functionalities.

Reference: “Methods for converting cysteine to dehydroalanine on peptides and proteins” Justin M. Chalker, Smita B. Gunnoo, Omar Boutureira, Stefanie C. Gerstberger, Marta Fernandez-Gonzalez, Goncalo J. L. Bernardes, Laura Griffin, Hanna Hailu, Christopher J. Schofield and Benjamin G. Davis; Chem. Sci. (2011) 2: 1666 – 1676.

Amounts Available: Compounds available as 50mg aliquots, please state if you wish to purchase the di-bromo or di-iodo compound in your enquiry – price on application.

The information presented here on these pages has been provided by the scientists and academics who have created the reagents. As far as Oxford University Innovation is able to establish this information is accurate but no representation is given as to its accuracy or completeness. It is the responsibility of the customer to determine the suitability for any purpose of the reagents and Oxford University Innovation shall not be liable for any claims, losses, liabilities, expenses or damages arising from any use of the materials. Nothing on these pages will form part of any contract or licence nor be regarded as a warranty or representation in relation to the products. Any supply would be subject to the terms and conditions of a separate agreement. Oxford University Innovation makes no representation that any item in this catalogue is not subject to third party intellectual property rights.

Request more

Ready to get in touch?

Contact Us
© Oxford University Innovation