2,5 dibromohexane diamide/2,3diiodo hexanediamide hybridoma
Reagents for the mild conversion of cysteine to dehydroalanine.
Using these reagents the conversion of cysteine to dehydroalanine proceeds at near neutral pH (8.0) and at 37°C with short reaction times (2-3 hours), this can be advantageous for fragile protein substrates such as antibodies and histones. The reagents can be used for site specific synthesis of S-linked glycoproteins, to incorporate mimics of posttranslational modifications and to generate amino acids with unnatural functionalities.
Reference: “Methods for converting cysteine to dehydroalanine on peptides and proteins” Justin M. Chalker, Smita B. Gunnoo, Omar Boutureira, Stefanie C. Gerstberger, Marta Fernandez-Gonzalez, Goncalo J. L. Bernardes, Laura Griffin, Hanna Hailu, Christopher J. Schofield and Benjamin G. Davis; Chem. Sci. (2011) 2: 1666 – 1676.
Amounts Available: Compounds available as 50mg aliquots, please state if you wish to purchase the di-bromo or di-iodo compound in your enquiry – price on application.
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