Probe for the detection of live mycobacteria
These compounds are incorporated into the cell envelope of mycobacteria, via the extracellular Ag85-enzymes, providing a means of detecting live organisms. These are the first small molecules that can be used to label and image tuberculosis in a selective manner in vivo.
Reference: “Uptake of unnatural trehalose analogs as a reporter for Mycobacterium tuberculosis” Keriann M Backus, Helena I Boshoff, Conor S Barry, Omar Boutureira, Mitul K Patel, François D’Hooge, Seung Seo Lee, Laura E Via, Kapil Tahlan, Clifton E Barry III & Benjamin G Davis; Nature Chemical Biology (2011) 7: 228–235.
Amounts available: 1mg or 5mg – price on application
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