TCR Transgenic Mouse Model, grb, dependent on HLA B27 for response

Strain: GRb-TCR-TG, Background: BALB/c

To study the potential roles and behaviour of an HLA B27-restricted T cell in vivo, a model system in which variable portions of a TCR (denoted GRb) originally derived from an HLA B27-positive volunteer are expressed as a transgene in an HLA B2705, human _2-microglobulin (h_2m)2 transgenic (TG) mouse using a mouse genomic cassette vector. The receptor is expressed and produces fully functional T cells in the context of HLA B27. CD4+ T cells expressing the TCR receptor can function as HLA B27-restricted T cells and are capable of differentiation to secrete cytokines indicative of either Th1 or Th2 subsets of T cells.

Fully Functional HLA B27-Restricted CD4+ as well as CD8+ T Cell Responses in TCR Transgenic Mice Matthew Roddis, Robert W. Carter, Mei-Yi Sun, Thomas Weissensteiner, Andrew J. McMichael, Paul Bowness, and Helen C. Bodmer Journal of Immunology, 2004, 172: 155–161.

 

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