Molecular Biophysics Suite (MBS)

The MBS offers a diverse range of techniques for macromolecule and molecular complex analysis.

The Biophysical Instrumentation Facility and its experienced team of scientists offer a range of techniques for the study and characterization of macromolecules and macromolecular complexes, particularly proteins.

Molecular Biophysics Suite techniques include:

  • Size Exclusion Chromatography Multiple Angle Light Scatter (SEC MALS)
  • Analytical Ultracentrifugation (AUC)
  • Circular Dichroism (CD)
  • Dynamic Light Scattering (DLS)
  • Fluorescence Spectroscopy (FS)
  • Isothermal Titration Calorimetry (ITC)
  • Differential Scanning Calorimetry (DSC)
  • Surface Plasmon Resonance (SPR)
  • Microscale Thermophoresis (MST)
  • Stopped Flow

Typical applications include:

  • characterisation of macromolecule solution behaviour by SEC MALS and AUC
  • protein stability by DSC and CD
  • affinity determination by SPR, MST and ITC

Based within the Department of Biochemistry, the facility staff are active users of the equipment in a broad research context and engage with clients to discuss project requirements fully.

Access to the Biophysics Facility can be provided through the facility manager Dr David Staunton: for

  • Submission of samples for analysis
  • In-house training  and hands-on use by client staff
  • Consultancy in the application of techniques

Past clients have included biotechnology and global pharmaceutical companies who have accessed a range of techniques to supplement internal resources and expand capabilities.

Molecular Biophysics Suite

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