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Catalytic amplification of faradic redox signal

Image from Licence Details: Catalytic amplification of faradic redox signal

Applications: Molecular detection, molecular quantification, electrochemical sensing, faradaic redox signalling

Features Benefits
  • Electrochemical sensing of proteins using shotgun tagging of proteins with biotin followed by protein-specific immunocapture and labelling using amplifying enzymes (poly(HRP)) to boost the electrochemical signal
  • Amplifying enzymes allow the method to quantify proteins down to fg/mL levels and across 5 orders of magnitude, while maintaining good specificity, even in complex matrices such as serum
  • This sensing method only requires a single bespoke binding event, during the protein-specific immunocapture stage
  • Requiring only one specific binding event means there are fewer variables and fewer steps, reducing assay time and cost
  • Tyramine-ferrocene is used as a HRP substrate to catalytically tether tyrosine molecules in the target proteins to tyrosine molecules on the electrode surface
  • Substrate tethering is time dependent and incubation time can be tailored to allow tuning of the assay dynamic range

Patented & available for:

  • Licensing
  • Co-development
  • Consulting
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