Home >Technologies Available >Technologies available for licensing

Enhanced Discriminatory Receptors (EDR) – enhancing discriminatory power of T cells

Image from Licence Details: Enhanced Discriminatory Receptors (EDR) – enhancing discriminatory power of T cells

Applications: CAR-T cell therapy

A platform technology that uses the T cell receptor alpha and beta chains to produce a CD3-independent enhanced discriminatory receptor exhibiting high on-target potency with dramatically reduced off-target cross-reactivity.

Features Benefits
  • Uses existing candidate TCRs
  • Improves efficacy and reduces cross-reactivity (without modifying the TCR variable domains, i.e. no CDR changes required)
  • Modified signalling enables selective responses to high affinity on-target antigens
  • Reduced or abolished responses to lower-affinity off-target antigens (i.e. reduced cross-reactivity)
  • Surface expression is CD3-independent
  • No mispairing with endogenous TCRs
  • High surface expression
  • Can be expressed in any cell (T cells, NK cells, macrophages, etc)

Patented and available for:

  • Licensing
  • Co-development
  • Consulting
Request more information
about this technology

Back to Technologies Available

Sparks Background Image

Ready to get in touch?

Contact Us
Sparks Background Image
© Oxford University Innovation