Enhanced Discriminatory Receptors (EDR) – enhancing discriminatory power of T cells
A platform technology that uses the T cell receptor alpha and beta chains to produce a CD3-independent enhanced discriminatory receptor exhibiting high on-target potency with dramatically reduced off-target cross-reactivity.
Applications: CAR-T cell therapy
| Features | Benefits |
|---|---|
| Uses existing candidate TCRs | Improves efficacy and reduces cross-reactivity (without modifying the TCR variable domains, i.e. no CDR changes required) |
| Modified signalling enables selective responses to high affinity on-target antigens | Reduced or abolished responses to lower-affinity off-target antigens (i.e. reduced cross-reactivity) |
| Surface expression is CD3-independent | No mispairing with endogenous TCRs |
| High surface expression | |
| Can be expressed in any cell (T cells, NK cells, macrophages, etc) |
Patented and Available For
- Co-development
- Consulting
- Licensing