These specialised sub-micron vaccine particles consist of a variable antigen shell surrounding an adjuvant core, designed to enhance immunogenicity while reducing the required vaccine dosage per patient. They hold potential for use in both traditional vaccines and tumour lysate-based cancer vaccines.
Features
Benefits
Ability to quickly incorporate any protein-derived antigen into the nanoparticle shell
Rapid adjustment of vaccine particle to pathogen of interest
A wide array of adjuvants or adjuvant combinations can be loaded into the nanoparticle core
Enhanced immune response, reducing the dose of vaccine per patient required
Antigen and adjuvant remain co-located post injection
Promotion of optimal immunogenicity
Particles have a similar size and morphology to a virus
Further enhancement of immune response
Established synthesis is a high yielding, two-step process that is compatible with scaling to a cGMP level
Rapid go-to-market and reduced manufacturing costs