Method for creating a nitric oxide generating coating for medical devices

Applications: Medical devices for cardiovascular disease, Cerebrovascular disease, Eye diseases and aneurysms.

A method for generating therapeutic gas, nitric oxide (NO), from a coating of amine-functionalised graphene that can be used for medical devices, such as stents.

Features	Benefits
Novel amine-functionalised graphene oxide material that generates NO, negating external NO sources.	Allows commercially viable in-vivo NO generating medical devices to be engineered.
Method provides a stable and strong coating that can be added to medical devices, and the coating thickness can be easily varied.	Maintains structural integrity and is non-toxic. Coating biodegradable medical devices has minimal effect on their degradation.
The coating generates therapeutic levels of NO in a sustained, controlled and slow manner at the site of need in the body, with trials ongoing.	Reduces the risk of medical complications after implantation of a medical device such as restenosis, bacterial infection and biofilm formation.
Straightforward and simple application of the coating using a dip coating method.	Can easily apply a smooth and uniform coating to complex 3D geometries and form factors. Cost-effective functionalisation approach. Scalable method of manufacturing medical devices.

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Method for creating a nitric oxide generating coating for medical devices

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