Production of T cells with enhanced antigen discrimination power

Applications: CAR-T cell therapy

Generation of T cells with genetic modifications that enhance their discriminatory powers resulting in highly potent on-target responses with dramatically lower off-target cross-reactivity without modifying the TCR.

Features	Benefits
Reduces cross-reactivity by modifying genes extrinsic to the TCR	Uses existing candidate TCRs (i.e. no modifications to the TCR are required) Maintains on-target potency
Modified signalling enables selective responses to high affinity on-target antigens	Reduced or abolished responses to lower-affinity off-target antigens (i.e. reduced cross-reactivity)
Simple genetic modifications	Dramatic ~10,000-fold reduction in cross-reactivity. Maintains on-target potency

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Production of T cells with enhanced antigen discrimination power

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