Production of T cells with enhanced antigen discrimination power
Generation of T cells with genetic modifications that enhance their discriminatory powers resulting in highly potent on-target responses with dramatically lower off-target cross-reactivity without modifying the TCR.
Applications: TCR-T cells
| Features | Benefits |
|---|---|
| Reduces cross-reactivity by modifying genes extrinsic to the TCR | Uses existing candidate TCRs (i.e. no modifications to the TCR are required) |
| Modified signalling enables selective responses to high affinity on-target antigens | Maintains on-target potency |
| Simple genetic modifications | Reduced or abolished responses to lower-affinity off-target antigens (i.e. reduced cross-reactivity) |
| Dramatic ~10,000-fold reduction in cross-reactivity | |
| Maintains on-target potency |
Patented and Available For
- Co-development
- Consulting
- Licensing