Recirculating ex-vivo organ dialyser for normothermic perfusion
This ex-vivo organ dialyser integrates a recirculating dialysate circuit with controllable transmembrane flux to continuously manage perfusate composition during normothermic perfusion. Using pumped influx/efflux, optional predilution, and ‘push-pull’ operation, it supports removal of metabolic waste and damage-associated species while maintaining volume control - designed as an adjunct to existing liver and kidney perfusion platforms.
Applications: Normothermic liver perfusion, normothermic kidney perfusion, extended organ preservation, organ quality optimisation, pre-transplant conditioning, perfusate homeostasis control, DAMPs clearance
| Features | Benefits |
|---|---|
| Closed-loop, recirculating dialysate circuit designed for portable operation without continuous water supply | Helps stabilise electrolytes and osmolality (and supports broader perfusate homeostasis) |
| Independent dialysate influx and efflux pumping to precisely control transmembrane flux | Supports continuous waste management to reduce accumulation of organ-derived and perfusate-derived by-products |
| Supplementary pumped predilution line for volume compensation and perfusate composition control | Enables tighter control of circulating volume and dilution strategies without relying on large fluid consumption |
| ‘Push-pull’ alternating transmembrane flux mode to reduce membrane pore blocking and improve clearance consistency | Improves operational flexibility for start/end-of-perfusion workflows (gradual perfusate introduction or flushing) |
| Optional high molecular weight cut-off dialysis capability for larger-molecule clearance strategies | Provides a route to monitor organ/perfusate state indirectly via dialysate composition and refresh decisions |
Patented and Available For
- Co-development
- Consulting
- Licensing