Semi-synthetic promoters for adenoviral-vectored transgene expression
A panel of compact, semi-synthetic promoters optimised for use in adenoviral vectors. By combining computationally designed synthetic enhancer elements with a compact core promoter, the technology enables robust transgene expression while significantly reducing promoter size. The synthetic enhancers are modular and can be paired with different core promoters, and span a range of activities, offering flexibility across a range of vector designs. This approach supports the inclusion of larger or multiple transgenes within a single vector, helping overcome payload limitations in adenoviral-vectored vaccine and gene delivery applications.
Applications: Adenovirus vectored vaccines, gene therapy vectors, viral vector engineering, transgene expression
| Features | Benefits |
|---|---|
| Compact promoter format optimised for payload-constrained vectors | Increases available vector space for larger genetic payloads or multiple expression cassettes |
| Semi-synthetic architecture combining synthetic enhancers with a compact core promoter | Matches the expression strength of industry-standard promoters despite the significantly reduced genomic footprint |
| Modular enhancers that span a range of activities and pair with different core promoters | Enables tuning of expression strength and flexibility across vector designs |
| Engineered to minimise sequence homology between enhancer variants | Improves genetic stability and reduces recombination risk in multi-cassette vectors |
| Compatible with viral-vectored vaccine and gene delivery platforms | Provides a versatile toolkit for next-generation viral vector design |
Patented and Available For
- Co-development
- Consulting
- Licensing