Accurate and comprehensive analysis of top-down mass spectra for the discovery of protein modifications
PrecisION is an analytical workflow and GUI-based software package enabling exhaustive, mechanism-informed interpretation of native top-down mass spectra. It combines unprecedented fragment-assignment logic, enhanced deconvolution routines, a hierarchical matching engine, and novel modification-discovery methods, enabling fully de novo spectral interpretation without reliance on incomplete proteoform databases.
Applications: Top-down mass spectrometry
| Features | Benefits |
|---|---|
| Novel mechanism-based fragment-assignment workflow | Delivers a step-change in interpretability by identifying sequence ions that current native TDMS pipelines systematically miss, especially in discovery-mode experiments |
| Advanced deconvolution routines optimised for native spectra | Produces cleaner, more reliable precursor and fragment mass assignments, enabling confident interpretation even for complex or partially unknown protein assemblies |
| De novo assignment of proteoforms without reliance on prior knowledgebases | Enables discovery of unexpected proteoforms, post translational modifications, chemical adducts, and sequence variants, unlocking biological insights inaccessible to database-dependent tools |
| Purpose-built for native top-down mass spectrometry as it enters mainstream analytical use | Increases the fraction of interpretable spectral information by more than threefold in typical datasets, transforming native TDMS from a niche technique into a powerful discovery-grade platform |
Awaiting patent and Available For
- Co-development
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