Yellowstone Biosciences spinout launches to advance cutting-edge cancer therapies from University of Oxford research
12th July 2024
Yellowstone Biosciences, a biotechnology spinout, has launched to pioneer new cancer treatments using advanced T-cell therapies based on groundbreaking research from the MRC Weatherall Institute of Molecular Medicine at University of Oxford.
Supported by Oxford University Innovation, the company will leverage over two decades of work by co-founder Professor Paresh Vyas to target common cancer proteins and revolutionise treatment options for patients.
The company secured a £16.5 million Series A funding round, led by the investment management firm Syncona Limited, which will drive the development of innovative treatments targeting specific cancer markers.
Over the past 20 years working in the MRC Molecular Haematology, Professor Vyas has compiled a unique biobank of over 10,000 samples from more than 3,000 acute myeloid leukaemia (AML) patients, including those cured through blood cell transplants. This extensive research has led to the discovery of new cancer markers that could enable highly targeted treatments.
“By targeting a groundbreaking new class of cancer markers, Yellowstone has the potential to significantly improve the treatment and extend the lives of patients with various forms of cancer, starting with acute myeloid leukaemia.” said Dr. Benedicte Menn, Senior Investment Manager at Oxford University Innovation.
“We are thrilled to see Yellowstone and Syncona collaborating on this important launch, and we will closely follow the development and success of their innovative pipeline. This partnership marks a significant step forward in our mission to bring cutting-edge research from the lab to the clinic, ultimately benefiting patients worldwide.”
Susan Campbell, Senior Licensing & Ventures Manager at Oxford University Innovation, added: “It has been a privilege to work with Paresh over recent years and to support his passion for improving patient treatment outcomes by harnessing the visionary insights that he has crystallised over years of clinical and academic work.
“By providing enabling connections with the diverse teams in OUI, the University and the UK Life Science Innovation ecosystem, it has been wonderful to support the creation of Yellowstone and thus to progress towards harnessing Paresh’s visionary insights to achieve the ultimate goal – to benefit patients. I look forward with great anticipation to the results that the company will deliver.”
The company’s initial focus will be on AML, which is responsible for 62% of leukaemia deaths and currently lacks a standard treatment for many patients. Yellowstone’s approach uses bispecific T-cell therapies designed to specifically attack cancer cells while sparing healthy ones by targeting markers presented by HLA-Class II molecules.
Beyond AML, Yellowstone’s technology holds promise for improving treatment and extending survival for other common cancers that express HLA-Class II markers, such as ovarian, lung, colorectal, prostate, breast, kidney cancers, and melanoma. This innovative approach aims to make a significant impact on the treatment landscape for these challenging diseases.
Professor Paresh Vyas, Co-founder and Chief Scientific Officer of Yellowstone, commented: “Therapeutically targeting common antigens has always been a challenge, but our two decades of research have uncovered a new class of targets that could treat cancer and improve patient survival.
“We believe our technology can precisely kill tumour cells while preserving healthy ones across various cancers. Together with Syncona, we are initially focusing on developing highly selective TCR-based therapies for AML, where we have extensive experience and data. Moving forward, we aim to expand our pipeline to include other cancers, maximising Yellowstone’s potential.”
Professor Vyas is part of the MRC Weatherall Institute of Molecular Medicine and the MRC Molecular Haematology Unit, part of the Radcliffe Department of Medicine at the University of Oxford.
(image via Unsplash)
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