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​​Accurate and comprehensive analysis of top-down mass spectra for the discovery of protein modifications

Image from Licence Details: ​​Accurate and comprehensive analysis of top-down mass spectra for the discovery of protein modifications

Applications: Top-down mass spectrometry

PrecisION is an analytical workflow and GUI-based software package enabling exhaustive, mechanism-informed interpretation of native top-down mass spectra. It combines unprecedented fragment-assignment logic, enhanced deconvolution routines, a hierarchical matching engine, and novel modification-discovery methods, enabling fully de novo spectral interpretation without reliance on incomplete proteoform databases.

Features Benefits
  • Novel mechanism-based fragment-assignment workflow
  • Delivers a step-change in interpretability by identifying sequence ions that current native TDMS pipelines systematically miss, especially in discovery-mode experiments
  • Advanced deconvolution routines optimised for native spectra
  • Produces cleaner, more reliable precursor and fragment mass assignments, enabling confident interpretation even for complex or partially unknown protein assemblies
  • De novo assignment of proteoforms without reliance on prior knowledgebases
  • Enables discovery of unexpected proteoforms, post translational modifications, chemical adducts, and sequence variants, unlocking biological insights inaccessible to database-dependent tools
  • Purpose-built for native top-down mass spectrometry as it enters mainstream analytical use
  • Increases the fraction of interpretable spectral information by more than threefold in typical datasets, transforming native TDMS from a niche technique into a powerful discovery-grade platform

Patent pending and available for:

  • Licensing
  • Co-development
  • Consulting
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