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A source localisation methodology to optimise sites of brain stimulation for therapeutic benefit

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Applications: Invasive and non-invasive brain stimulation, neuromodulation, neurostimulation, deep brain stimulation, electrode implantation.

Features Benefits
  • An algorithm to spatially localise sources of pathological oscillatory brain activity in 3D-space by using traveling waves generated by these sources.
  • Enables optimisation of shape and volume of the stimulation field to target the clinically beneficial hotspot within the relevant brain structure.
  • Automated method to guide both (i) electrode placement (during implantation or positioning) and (ii) contact selection.
  • Methodology validated in a proof-of-concept study (20 hemispheres of patients with Parkinson’s disease implanted with DBS electrodes).
  • Faster and more efficient than current method of trial-and-error.
  • Reduces number of visits and duration to optimise stimulation parameters and stimulation contact for patients undergoing DBS treatment, thereby improving patient experience.
  • Methodology relies on identifying pathological activity using its intrinsic spatio-temporal dynamics.
  • The technique could help guide implantation more precisely once the recording contacts are close to the target.
  • Methodology is independent of amplitude of neural activity.
  • Not affected by type of stimulation contact, e.g. biophysical properties, surface sizes or shapes of electrodes can lead to variation in contact impedances, which results in differences in signal amplitude and/or noise level between contacts.
  • A fast dynamic algorithm, able to provide frequent source position updates.
  • Improves how neural stimulation is applied on a regular basis, providing a spatially more precise way to guide brain stimulations (including closed-loop brain stimulation).

Patented and Available for:

  • Licensing
  • Co-development
  • Consulting
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