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Electrochemical method of sensing target protein molecules

Image from Licence Details: Electrochemical method of sensing target protein molecules

Applications: Protein detection, protein quantification, protein assaying

 

Features Benefits
  • A method of electrochemical protein quantification involving shotgun redox tagging a protein mixture then specifically recruiting the target protein at an antibody-modified electrode surface
  • The method is able to discriminate between the target protein and other non-specific proteins with minimal background interference and a high signal-to-noise ratio
  • The method can be integrated into a microfluidic setup (see image) which could be automated to allow the method to be highly scalable
  • Integration of a sample protein into the microfluidic system decreased the limit of detection (0.1pg/mL) and required a very small sample (25μg/mL)
  • Work done on this assay method demonstrates that it can be used for simple and sensitive detection of protein biomarkers
  • This approach is able to achieve a very low limit of detection while still being applicable across a dynamic range which spans 6 order of magnitude
  • This assay is generic and can be used to analyse several proteins simultaneously by using an array of electrodes
  • The method, particularly when integrated into a microfluidic system, is rapid and scalable, leading to a huge reduction in costs and labour requirements

Patented & available for:

  • Licensing
  • Co-development
  • Consulting

Learn more – enquiries@innovation.ox.ac.uk

Browse more opportunities – www.innovation.ox.ac.uk

 

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