Increasing the potential of the next generation therapeutic oligonucleotides

Image from Licence Details: Increasing the potential of the next generation therapeutic oligonucleotides

Applications: Oligonucleotide chemistry, biopharmaceuticals, molecular diagnostics, biomaterials, RNAi therapeutics

Chemical synthesis strategy for increasing the stability and biocompatibility of chemically-synthesised therapeutic oligonucleotides to enable broader medical application of the technology.

Features Benefits
  • Causes more selective and stronger binding to complementary nucleic acids within RNA/DNA complexes -higher target affinity and specificity
  • Form stable duplexes with RNA, and importantly have selectivity for RNA over DNA
  • Causes minimal structural deviation to the nucleic acid and increases stability
  • Less susceptibility to enzymatic degradation than native DNA/RNA
  • Ability to modulate or eliminate anionic charge on DNA/RNA analogue
  • Creates more robust, inert and stable DNA or RNA molecules
  • Synthesis by rapid, efficient and scalable solid phase techniques
  • Well structured manufacture and production processes
  • Exceptional stability in biological media, and crucially in cell studies
  • Improves cell uptake of nucleic acids
  • Highlights the therapeutic potential of the technology to address RNA targets in many diseases
  • Wide range of applications
  • Potential applications in oligonucleotide chemistry, biopharmaceuticals chemical biology, nanotechnology, nanomedicine, molecular diagnostics, and biomaterials
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