A novel redox capacitive biosensor assay based on a phytic acid-doped PANI polymer

Image from Licence Details: A novel redox capacitive biosensor assay based on a phytic acid-doped PANI polymer

Figure 1 Schematic diagram and results of this method in an exemplary application using cardiac biomarker CRP


Applications: Molecule detection, molecule quantification, electrochemical impedance spectroscopy (EIS), capacitance spectroscopy, redox capacitance


Features Benefits
  • A reagentlesscapacitive approach to electrochemical impedance spectroscopy that avoids the use of ferrocene
  • Excellent baseline stability (≤2% drift over 7h after an initial stabilization over 30 min) and good resistance to non-specific protein adsorption
  • Utilises phytic acid-doped polyaniline (PANI-Pa) as a novel redox capacitive polymer support
  • Tested on CRP, a well-characterised cardiac biomarker, but easily translated to any conductive surface and any biomarker of interest
  • Facile assembly of the PANI film via electropolymerisation
  • Sensitivity of the assay can be varied through manipulation of film thickness (which alters the scale and time frame measured) and assay method allows increased receptor loading compared to previous methods.
  • Consists of a receptor bound to the PANI-Pa film that is capable of binding the target compound
  • The method allows selective assaying across a range of magnitudes with a very low limit of detection (0.5 μg/mL for the biomarker CRP)

Patented & available for:

  • Licensing
  • Co-development
  • Consulting

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