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Rhodium catalysed cross-coupling approach to enantioenriched piperidines

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Applications: Chemical Synthesis, Catalysis, Drug Discovery; optimised synthetic routes to commercially available clinical drugs

Oxford researchers have developed a novel method to access enantioenriched dihydropyridines – these dihydropyridines are precursors to chiral piperidines known for diverse biological activities.

Features Benefits
  • New method to access enantioenriched dihydropyridines.
  • Dihydropyridines are precursor to chiral piperidines known for diverse biological activities.
  • Rhodium catalysed enantioselective carbometallation reaction.
  • Enantioenriched dihydropyridine can be produced via a two-step mechanism.
  • Avoids costly and low yielding industrial enantioenrichment methods.
  • Provides access to commercially available clinical drugs in three to four steps.
  • Fewer steps than standard routes.
  • Higher efficiency and yields.
  • Reduced manufacturing costs.
  • This method can provide a library of chiral piperidines.
  • New leads for new candidates in drug discovery.
  • Applicable to non-substituted and substituted pyridines.

Patented and available for:

  • Licensing
  • Co-development
  • Consulting
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