Fabricating arrays of nanopores self-aligned with on-chip nanostructures

Applications: DNA Sequencing, Data Storage, Analyte Detection, Biosensing

Researchers at the University of Oxford have developed a new method to fabricate individual or arrays of nanopores self-aligned with on-chip electrodes.

Features	Benefits
Nanopores are created by applying a breakdown voltage between an on-chip electrode and an electrolyte solution in contact with the other side of the membrane.	Can be performed using inexpensive equipment. Doesn’t require a highly experienced user and the process can be automated. Process is rapid compared to current techniques.
The applied electric field is localised to the on-chip electrode.	Can independently fabricate and localise multiple nanopores simultaneously.
Serves as an extension of controlled breakdown technique where nanopores can be precisely self-aligned with complementary nanostructures.	No additional equipment or fabrication steps are needed for alignment with on-chip electrodes. Creates nanopores in the electrolyte environment in which measurements will be performed.
The complementary nanostructures can provide alternate detection modalities to ionic current based sensing typically used for nanopore sensing.	Biosensors can be developed with increased device bandwidth, higher device densities, and higher sensitivity to additional molecular properties.

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Fabricating arrays of nanopores self-aligned with on-chip nanostructures

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