Method to generate human bone organoid
A method for generating ex vivo models of the bone and bone marrow, which involves the use of a fragmented gel as a 3D scaffold to drive vascularisation and differentiation.
Applications: Modelling cell-cell interactions, testing/validating pharmacological agents, personalised medicine approaches, cytotoxicity screens, modelling mechanisms of bone marrow metastasis, drug discovery, generation of cells for autologous/allogenic cell transpla
| Features | Benefits |
|---|---|
| This method uses a microgel (or a fragmented/granular hydrogel) | A complex 3D environment including a lumen forming vasculature, haemopoietic cells and mineral depositing bone progenitors can be formed |
| Can generate bone marrow organoids at high scale | Can supply academic and commercial researchers in a cost-effective manner |
| A more complex cellular milieu can be formed, which includes bone progenitors/bone depositing cells, as well as haematopoietic (lymphoid and myeloid) cells and a functioning vasculature | This allows reproducibility of the biology of the bone and bone marrow, allowing modelling of a broader range of diseases |
| The structures generated with a fragmented microgel are more cellular, with fewer non-cellular gel-rich gaps form between vessels | This increases cell-cell interactions to yield a more mature, physiologically relevant culture |
| Allows discovery and testing of new therapeutics on patient samples in a 3D microenvironment | Allows evaluation of selectivity of targeted therapies and impact of specific tissue environments on efficacy of therapeutic agents; Can lead to personalised medicine approaches |
Patented and Available For
- Co-development
- Licensing