Novel variants of cell penetrating peptides to improve therapeutic delivery
A new CPP design optimises Arginine placement to boost delivery efficiency and minimise toxicity, resulting in significantly improved therapeutic delivery performance.
Applications: Drug delivery, gene therapy, diagnostics, RNA therapeutics, personalised medicine
| Features | Benefits |
|---|---|
| A small CPP able to effectively transport other molecules into cells | Favourable efficacy of therapeutic delivery with good penetrance to a target cell of interest |
| Can be covalently linked to a range of therapeutic molecules | Enables delivery of varied therapeutic cargo molecules including, but not limited to antisense oligonucleotide therapies, targeting both systemic and rare diseases |
| Novel arginine rich and hydrophobic domains with improved characteristics | The position of the arginine residues determines efficacy/toxicity trade-off of CPPs, and arrangement is optimised for less toxicity compared to current CPPs as demonstrated in vivo after systemic delivery suggesting improved clinical applicability |
| Demonstrated efficacy in skeletal muscles both in vitro and in vivo with therapeutic cargo | Enables targeted therapies, such as for heritable genetic diseases of neuromuscular and musculoskeletal systems with proof-of-concept in a mouse model of Myotonic Dystrophy |
Patented and Available For
- Co-development
- Consulting
- Licensing