Hydrogen driven enzymatic recycling of flavin cofactors

Applications: Enzymatic industrial processes

Despite the positive environmental and chemical potential of enzymatic catalysis, its use in industry has been limited due to lack of robust systems for recycling enzyme cofactors. This has led to use them in superstoichiometric quantities, thus increasing the cost of the process and amounts of chemical waste. The current invention targets such challenge and presents a novel recycling method for flavin cofactors.

Features	Benefits
Uses hydrogen to reduce an oxidised flavin co-factor	Improved atom efficiency Hydrogen is readily available and replaces the need for glucose
Only requires a single enzyme for flavin reduction	Easier recycling of flavin co-factors Reduces the need for additional equipment and learning of new techniques
The reaction is catalysed by E.coli hydrogenases (Hyd1)	Environmentally friendly – Hyd1 enzymes are renewable and biodegradable
Reduced flavin is continually regenerated	Reduced flavin can be used in downstream enzyme-catalysed reactions

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Hydrogen driven enzymatic recycling of flavin cofactors

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