Hydrogen driven enzymatic recycling of flavin cofactors

Image from Licence Details: Hydrogen driven enzymatic recycling of flavin cofactors

Applications: Enzymatic industrial processes

Despite the positive environmental and chemical potential of enzymatic catalysis, its use in industry has been limited due to lack of robust systems for recycling enzyme cofactors. This has led to use them in superstoichiometric quantities, thus increasing the cost of the process and amounts of chemical waste. The current invention targets such challenge and presents a novel recycling method for flavin cofactors.

Features Benefits
  • Uses hydrogen to reduce an oxidised flavin co-factor
  • Improved atom efficiency
  • Hydrogen is readily available and replaces the need for glucose
  • Only requires a single enzyme for flavin reduction
  • Easier recycling of flavin co-factors
  • Reduces the need for additional equipment and learning of new techniques
  • The reaction is catalysed by E.coli hydrogenases (Hyd1)
  • Environmentally friendly – Hyd1 enzymes are renewable and biodegradable
  • Reduced flavin is continually regenerated
  • Reduced flavin can be used in downstream enzyme-catalysed reactions

Available for:

  • Licensing
  • Co-development
  • Consulting
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