Enzymatic method for the synthesis of hydrogen isotope labelled compounds

Applications: Generation of highly selective labelled enzyme cofactors and labelled products

Incorporation of deuterium in molecules can induce useful changes in properties relative to their corresponding isotopologues. Deuterated pharmaceuticals, long used in diagnostic studies, are being re-evaluated for therapeutic properties. However, existing methods to incorporate deuterium are expensive, unsafe, and lack selectivity and atom-efficiency. The present invention describes a method to produce hydrogen isotope labelled co-factors, and its use in enzymatic production of deuterated molecules.

Features	Benefits
Reduced hydrogen isotope labelled co-factors are generated from hydrogen isotope ions in solution and a non-labelled reductant.	Reduced cost and ease of operation of the method. Eliminates the need for expensive and dangerously reactive chemical agents.
Labelled reduced co-factor are used in the enzymatic reductions of molecules.	Facile synthesis of labelled reduced molecules.
Labelled co-factors are re-oxidised and reduced many times through the enzymatic process, thereby recycling the cofactor.	Ensures the process is economically feasible as there is no requirement for stoichiometric additions.
No requirement for exogenous co-substrates to mediate the transfer of hydrogen isotope ions to the oxidised co-factors.	Efficient, atom-economical and clean process.

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Enzymatic method for the synthesis of hydrogen isotope labelled compounds

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